PRP Mechanism of Action
To understand why PRP (Platelet-Rich Plasma) is so effective in medicine and aesthetics, we need to look at its mechanism of action.
PRP is actually a blood product made from the patient’s own blood. First, a small amount of blood is drawn, and then placed in a centrifuge. The centrifuge rapidly separates blood components by their specific gravity. As a result, the platelets—rich in growth factors—are concentrated in a distinct layer. This layer is known as PRP, or Platelet-Rich Plasma.
Platelets in the body are not only responsible for clotting, but also contain special proteins and growth factors that can activate tissue repair and regeneration processes. When PRP is injected into the skin or other target areas, these factors stimulate stem cells and boost the production of collagen and elastin. This leads to fresher skin, stronger hair, and quicker wound healing.
For example:
- In skin aesthetics, these growth factors increase the thickness and elasticity of the skin.
- In hair loss treatment, they stimulate weak hair follicles and activate the hair growth cycle.
- In sports medicine and orthopedics, these factors help speed up the repair of ligaments and tendons.
Put simply, PRP works by harnessing the body’s natural ability to heal itself, but this process is boosted and accelerated by injecting concentrated plasma.
Aesthetic Applications of PRP
In recent years, PRP (Platelet-Rich Plasma) has become one of the most popular non-surgical cosmetic treatments. Its popularity comes from the natural process involved and its low risk—since the blood comes from the patient, allergic reactions and treatment rejection are very rare.
The most important aesthetic applications of PRP include:
Facial Skin Rejuvenation
Injecting PRP into facial skin increases the production of collagen and elastin. The result is firmer, brighter skin with fewer wrinkles. For this reason, PRP is often called the “natural anti-aging treatment.”
Hair Loss Treatment
One of the most popular uses of PRP is for hair loss. When injected into the scalp, PRP stimulates hair follicles and activates the growth cycle. This method has shown good results both for men with hereditary hair loss and for women with thinning hair.
Reducing Dark Circles and Hollowness Under the Eyes
PRP can reduce darkness and hollowness under the eyes by improving blood circulation and boosting tissue regeneration. Unlike fillers, which are temporary, this method improves the quality of skin in the under-eye area.
Improving Scars and Acne Marks
Injecting PRP into areas with scars or acne marks stimulates cell regeneration, gradually smoothing the skin and lessening the appearance of scars.
Combining with Other Aesthetic Treatments
PRP is effective on its own, but many clinics combine it with treatments like microneedling or laser skin rejuvenation. In this case, the microchannels created by needles or laser enhance PRP absorption and amplify its effects.
Overall, the aesthetic applications of PRP are rooted in naturally triggering the body’s regeneration process, making it a safe, natural, and effective option.
Medical Applications of PRP
Beyond aesthetics, PRP (Platelet-Rich Plasma) has earned an important place in regenerative medicine and non-surgical therapies, owing to its tissue-healing abilities and stimulation of the body’s natural processes.
Orthopedics and Joint Injury Treatment
One of the best-known medical areas that uses PRP is orthopedics. Injecting PRP around injured joints can reduce inflammation and stimulate cartilage repair.
- In the United States, PRP is used to treat knee osteoarthritis and ligament injuries in professional athletes.
- In Turkey, modern sports clinics have included PRP as part of rehabilitation protocols after sports injuries.
- In Russia, this method is recommended for professional football and hockey players.
Tendon and Ligament Repair
Tendon injuries (like tennis elbow or Achilles tendon injuries) are often hard to treat. PRP injections help accelerate healing by increasing blood flow and stimulating cell regeneration.
Dental and Oral & Maxillofacial Surgery
PRP is used in dentistry for gum repair, treating periodontal disease, and improving the healing of surgical wounds in the jaw. In Iran and Gulf countries, PRP has also become very popular for dental implant procedures.
Reconstructive Surgery and Burns
Patients with extensive burns or chronic wounds (like diabetic foot ulcers) often face repair challenges. PRP injections in these cases can speed up skin and soft tissue regeneration. In China, this treatment is part of the standard care in burn clinics.
Gynecology and Obstetrics
Some specialized clinics use PRP to improve vaginal tissue quality and treat issues like dryness or reduced elasticity. PRP is also used in post-partum recovery.
Steps of PRP Procedure
The PRP process is simple yet requires expertise, and must be done in reputable clinics by trained doctors or specialists. The first step is to draw a blood sample, usually about 10–20 ml, similar to a routine lab test. The blood is then placed in a centrifuge, which spins at high speed to separate the components according to their specific gravity. This produces platelet-rich plasma, isolated from red and white blood cells.
Next, the treatment area is prepared. Depending on the purpose, the skin or scalp is cleaned with antiseptics, and if needed, local numbing cream is used to minimize discomfort. The PRP is then injected into the target area with fine needles or with special devices (like dermapen for the skin). Injections are made at multiple points to ensure even distribution.
The entire process typically takes 30 to 60 minutes, after which the patient can resume normal activities. It’s advised to avoid washing the area or using makeup/products for several hours after treatment. To achieve the best results, several sessions—spaced a few weeks apart—are usually required. The number of sessions depends on the type of issue, age, and the doctor’s assessment.
PRP Compared to Similar Treatments
When it comes to skin rejuvenation and hair loss treatment, there are plenty of options, each with their own benefits and limitations. Here, we compare PRP with some other common methods to help you make an informed choice.
PRP vs. Mesotherapy
Mesotherapy involves injecting ready-made cocktails of vitamins, minerals, and strengthening agents into the skin or scalp. While mesotherapy introduces external substances, PRP is derived from your own blood, greatly lowering the risk of allergies or side effects. Thanks to its natural growth factors, PRP is also more long-lasting than mesotherapy.
PRP vs. Microneedling
Microneedling stimulates collagen production by creating micro-injuries in the skin. It is effective on its own, but when combined with PRP (a treatment often called the “vampire facial”), the results are far better and appear much faster. Thus, microneedling is a great complement for PRP.
PRP vs. Laser Skin Rejuvenation
Lasers stimulate the skin by delivering energy to various layers, encouraging repair and collagen production. However, they may not suit all skin types and sometimes cause extended redness or pigmentation. In contrast, PRP has fewer limitations and is suitable for a wide range of skin types. While lasers give faster results, PRP offers a more natural, gradual improvement.
PRP vs. Hair Transplant
For those with severe, widespread hair loss, hair transplantation may be the only definitive solution. However, PRP can be used as a supplemental treatment before and after transplant, strengthening follicles and increasing blood supply, resulting in higher quality transplanted hair and faster scalp recovery.
Side Effects and Aftercare Following PRP
No cosmetic treatment is entirely without side effects, even if it uses your own blood. Fortunately, the side effects of PRP are usually mild and temporary, resolving within a short period. Knowing about them and following aftercare recommendations can greatly improve your results.
Possible Side Effects of PRP
After treatment, you may experience:
- Swelling and redness: At the injection site, especially on the face or scalp, usually resolving within 24–48 hours.
- Mild bruising or pain: Caused by needle entry, more common in people with sensitive skin.
- Temporary itching or burning: Usually due to skin irritation.
- Infection (rare): Only if sterile technique is not followed in the clinic.
Aftercare for PRP
To get the best result from your treatment, follow these instructions:
- Don't wash the treated area for 24 hours after treatment.
- Avoid direct sunlight and use suitable sunscreen.
- Refrain from heavy exercise, sauna, and swimming for at least 48 hours.
- Drink plenty of water to support cell regeneration and keep skin hydrated.
- Avoid blood-thinning medications (like aspirin and ibuprofen) for several days after treatment (unless prescribed by your doctor).
- Use cold compresses if you experience swelling or bruising.
Overall, following aftercare helps any mild side effects resolve quickly and ensures optimal tissue repair and collagen production.
PRP Cost and Availability in Different Countries
The cost of PRP Platelet-Rich Plasma varies by country, clinic, number of sessions, and equipment used. Exchange rates and the local economy in each country directly impact the price. Looking at several countries reveals the following:
- Iran: The average cost per PRP session for skin or hair is $150 to $300, depending on the city and doctor's expertise.
- Turkey: With modern facilities and medical tourism, costs generally range from $250 to $450 per session.
- Iraq (Kurdistan & Baghdad): The approximate price is between $200 and $350; access to equipped clinics is easier in big cities.
- Russia: Costs range from $200 to $500, being higher in major cities like Moscow and St. Petersburg.
- USA: Each PRP session is typically $300 to $700, and on average, three sessions are recommended for optimal results.
- China and Gulf countries: Prices vary between $250 and $600; equipped clinics are active in major cities and medical tourism destinations.
Key Notes for Accessing PRP
- Use reputable, officially licensed clinics to ensure treatment quality and safety.
- The usual treatment plan is 3 to 6 sessions, spaced 4 to 6 weeks apart, for optimal results.
- Many clinics—especially in developed countries—offer online consultations and pre-visit assessments.
With this information, people can select the best option according to their budget and circumstances, both in their own country or abroad, and confidently access PRP treatment.
Conclusion
Treatment with PRP Platelet-Rich Plasma is one of the latest and most effective methods for skin beauty and hair loss treatment. The treatment plan varies based on each individual’s body condition, age, and the type of concern. This minimally invasive method does not require surgery and its quick recovery is a key advantage for many. As seen, the cost and access to PRP differs based on the local economy and clinic facilities—but with the right choice, you can achieve the best results.
SharMarket is an international, comprehensive platform introducing beauty and medical services worldwide. With SharMarket, users can find reputable clinics and treatment centers in different countries such as Iran, Turkey, Russia, USA, China, and Gulf countries, compare prices and services, and make smart, informed choices.
